ABSTRACT
Abstract: Histiocytoses are rare diseases caused by the proliferation of histiocytes. The pathogenesis remains unknown and the highest incidence occurs in pediatric patients. The clinical presentations can be varied, in multiple organs and systems, and the skin lesions are not always present. Evolution is unpredictable and treatment depends on the extent and severity of the disease. It is described the case of a patient with various neurological symptoms, extensively investigated, who had its was diagnosed with histiocytosis from a single skin lesion. This report highlights the importance of Dermatology in assisting the investigation of difficult cases in medical practice.
Subject(s)
Humans , Male , Middle Aged , Skin/pathology , Skin Diseases/pathology , Histiocytosis, Langerhans-Cell/pathology , Bone Diseases/diagnostic imaging , Brain Diseases/diagnostic imaging , Magnetic Resonance Spectroscopy , Eosinophilic Granuloma/pathology , Eosinophilic Granuloma/diagnostic imaging , Histiocytosis, Langerhans-Cell/diagnostic imaging , Fatal OutcomeABSTRACT
Abstract Clinical presentation of paracoccidioidomycosis (PCM) can be diverse. Morphology and quantity of skin lesions depends on interactions between host immunity and fungus virulence. Diagnosis can be a challenge considering that this fungus has low virulence and some individuals have immunity to microorganism, which results in well-marked granulomas without visible microorganisms. We report herein a clinical presentation of sarcoid-like PCM, initially diagnosed as tuberculoid leprosy. This rare type of PCM is often mistaken for other types of chronic granulomatous diseases. Diagnosis was confirmed after 4 years when a special stain analysis helped in the identification of the specific etiologic agent.
Subject(s)
Humans , Female , Adult , Paracoccidioidomycosis/diagnosis , Sarcoidosis/diagnosis , Leprosy, Tuberculoid/diagnosis , Paracoccidioidomycosis/pathology , Paracoccidioidomycosis/drug therapy , Sarcoidosis/pathology , Diagnosis, DifferentialABSTRACT
Abstract: A patient with systemic involvement, initially treated as tuberculosis, is presented in this report. There were only two painful subcutaneous nodules, from which we arrived at the correct diagnosis of histoplasmosis. The patient was attended by several experts in the fields of infectious diseases, nephrology and internal medicine, but the diagnosis was only possible after dermatological examination and skin biopsy. This case values multidisciplinary interaction between dermatologists and other medical areas for diagnosis of cases with atypical manifestations.
Subject(s)
Humans , Male , Subcutaneous Tissue/microbiology , Dermatomycoses/diagnosis , Histoplasmosis/diagnosis , Arm , Biopsy , Interdisciplinary Communication , Diagnosis, Differential , Diagnostic Errors/prevention & controlABSTRACT
Apresenta-se um caso raro de osteoartropatia hipertrófica secundária a um mesotelioma pleural maligno difuso tipo misto, com diagnóstico clínico-radiológico inicial de abscesso pulmonar, em uma jovem de 17 anos de idade
Subject(s)
Adolescent , Humans , Female , Mesothelioma/complications , Osteoarthropathy, Primary Hypertrophic/etiology , Pleural Neoplasms/complications , Mesothelioma/pathology , Pleural Neoplasms/pathologyABSTRACT
Relatamos a ocorrência de cistos do ducto do tiroglosso com carcinoma papilífero numa india Txukahamäe do Parque Nacional do Xingu. A punçäo aspirativa com agulha fina do cisto do ducto do tiroglosso possibilitou o diagnóstico pré-cirúrgico do carcinoma. O exame anatomopatológico do conjunto extraído confirmou cistos do ducto do tiroglosso e carcinoma papilífero.